In 2013, the American Psychiatric Association’s DSM-5 included an Outline for Cultural Formulation (OCF), revised from the one included in DSM-IV, and a new Cultural Formulation Interview (CFI) of 16 questions to help clinicians obtain information for the OCF. The OCF includes (1) cultural identity, (2) cultural concepts of distress, (3) cultural stressors and supports, (4) cultural features of the clinician-patient relationship, and (5) overall assessment for diagnosis and treatment planning. Francis Lu, MD, Kim Professor in Cultural Psychiatry, Emeritus, UC Davis, reviewed the rationale for these two clinical tools to incorporate cultural issues in diagnosis and treatment, a roadmap to where cultural issues appear in DSM-5, and an overview of the OCF and CFI.